Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.35 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL1237356 | 0.97 | TP53 (0.61) | TP53ALDH1A1TSHRMEN1KMT2A | |
| Ether SCHEMBL8206941 | 0.83 | TP53 (0.40) | TP53ALDH1A1TSHRCHRM1AKR1A1 | |
| Cadaverine Tartrate SCHEMBL2963333 | 0.81 | TSHR (0.56) | TP53OR51E2ALDH1A1TSHRCHRM1 | |
| Ether SCHEMBL9389158 | 0.81 | TP53 (0.38) | TP53OR51E2ALDH1A1TSHRCHRM1 | |
| Ether SCHEMBL2574859 | 0.80 | OR51E2 (0.67) | TP53OR51E2ALDH1A1GPR84FFAR1 | |
| Ether SCHEMBL9225910 | 0.80 | ALDH1A1 (0.43) | ALDH1A1TSHRHDAC1HDAC2TDP1 | |
| Ether SCHEMBL3501247 | 0.80 | ALDH1A1 (0.43) | ALDH1A1TSHRTDP1 | |
| Lactic Acid SCHEMBL27721040 | 0.80 | — | — | |
| Lactic Acid SCHEMBL248090 | 0.80 | — | — | |
| L-Lactic Acid SCHEMBL5921449 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604196-A | Nonflammable mild odor solvent cleaner with (m)ethyl lactate and propylene glycol propyl ether | LOCKHEED CORPORATION (US) | 1997-02-18 | — | — | US | disclosed |