Sugi Predict

Sugi Predict / Compounds / SCHEMBL8930994

SCHEMBL8930994

SCHEMBL8930994

NC1=C(Nc2ccccc2)C(=O)c2ccccc2C1=O

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADORA2A P29274 2/20 0.68
▸ NPC1 O15118 9/20 0.67
▸ RAB9A P51151 9/20 0.67
▸ KMT2A Q03164 8/20 0.67
▸ MEN1 O00255 7/20 0.67
▸ MAPT P10636 10/20 0.61
▸ HTT P42858 7/20 0.61
▸ LMNA P02545 6/20 0.61
▸ SMN1; SMN2 Q16637 5/20 0.61
▸ MAPK1 P28482 5/20 0.61
▸ MITF O75030 4/20 0.61
▸ GAA P10253 4/20 0.61
▸ NPSR1 Q6W5P4 4/20 0.61
▸ ATM Q13315 2/20 0.61
▸ XBP1 P17861 1/20 0.61
▸ ALDH1A1 P00352 4/20 0.58
▸ L3MBTL1 Q9Y468 4/20 0.58
▸ POLB P06746 3/20 0.58
▸ HPGD P15428 1/20 0.58
▸ DHODH Q02127 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7912341 0.85 MAPT (0.73) NPC1RAB9AKMT2AMEN1MAPT
Anthraquinone SCHEMBL28378374 0.78 MEN1 (0.63) NPC1RAB9AKMT2AMEN1MAPT
Anthraquinone SCHEMBL28323700 0.78 MEN1 (0.63) NPC1RAB9AKMT2AMEN1MAPT
SCHEMBL2464502 0.77 NPC1 (0.62) ADORA2ANPC1RAB9AKMT2AMEN1
SCHEMBL29633261 0.76 MAPT (1.00) NPC1RAB9AKMT2AMEN1MAPT
SCHEMBL7913503 0.76 MAPT (0.61) NPC1RAB9AKMT2AMEN1MAPT
SCHEMBL6506683 0.76 MAPT (1.00) NPC1RAB9AKMT2AMEN1MAPT
SCHEMBL1510327 0.75 RAB9A (0.68) ADORA2ANPC1RAB9AKMT2AMEN1
SCHEMBL29563346 0.75 RAB9A (0.68) ADORA2ANPC1RAB9AKMT2AMEN1
SCHEMBL7918722 0.74 MAPT (0.62) NPC1RAB9AKMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200149112-A1 AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES THE JOHNS HOPKINS UNIVERSITY 2020-05-14 — — US disclosed
US-10227654-B2 Agents for reversing epigenetic silencing of genes THE JOHNS HOPKINS UNIVERSITY (US) 2019-03-12 — — US disclosed
US-20150252438-A1 AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES THE JOHNS HOPKINS UNIVERSITY 2015-09-10 — — US disclosed
US-9034574-B2 Agents for reversing epigenetic silencing of genes THE JOHNS HOPKINS UNIVERSITY (US) 2015-05-19 — — US disclosed
US-9034574-B2 Agents for reversing epigenetic silencing of genes THE JOHNS HOPKINS UNIVERSITY (US) 2015-05-19 — — US disclosed
US-8187727-B2 Imidazole derivatives, preparation method thereof and organic electronic device using the same LG CHEM, LTD. (KR) 2012-05-29 — — US disclosed
US-8187727-B2 Imidazole derivatives, preparation method thereof and organic electronic device using the same LG CHEM, LTD. (KR) 2012-05-29 — — US disclosed
WO-2007011170-A9 NEW IMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND ORGANIC ELECTRONIC DEVICE USING THE SAME LG CHEM. LTD. (KR) 2011-06-16 — — WO disclosed
EP-1907366-B1 NEW IMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND ORGANIC ELECTRONIC DEVICE USING THE SAME LG CHEMICAL LTD (KR) 2010-04-28 — — EP disclosed
US-20100093768-A1 Agents for Reversing Epigenetic Silencing of Genes THE JOHNS HOPKINS UNIVERSITY 2010-04-15 — — US disclosed
US-20100093768-A1 Agents for Reversing Epigenetic Silencing of Genes THE JOHNS HOPKINS UNIVERSITY 2010-04-15 — — US disclosed
WO-2008083098-A1 AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES THE JOHNS HOPKINS UNIVERSITY (US) 2008-07-10 — — WO disclosed
US-20070018155-A1 New imidazole derivatives, preparation method thereof and organic electronic device using the same LG CHEM. LTD. (KR) 2007-01-25 — — US disclosed
US-20070018155-A1 New imidazole derivatives, preparation method thereof and organic electronic device using the same LG CHEM. LTD. (KR) 2007-01-25 — — US disclosed
WO-2007011170-A1 NEW IMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND ORGANIC ELECTRONIC DEVICE USING THE SAME LG CHEM. LTD. (KR) 2007-01-25 — — WO disclosed
CN-1006386-B PROCESS FOR PRODUCTION OF VINYL CHLORIDE POLYMER SHINETSU CHEM IND CO (JP) 1990-01-10 — — CN disclosed
CN-85107531-A Process for producing vinyl chloride polymer — 1987-01-21 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200149112-A1 AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES MECP2, MBD2, GATAD2B ADORA2A 3196/4885NPC1 4094/4885RAB9A 3374/4885
US-10227654-B2 Agents for reversing epigenetic silencing of genes MECP2, MBD2, GATAD2B ADORA2A 3196/4885NPC1 4094/4885RAB9A 3374/4885
US-20100093768-A1 Agents for Reversing Epigenetic Silencing of Genes MECP2, MBD2, GATAD2B ADORA2A 3196/4885NPC1 4094/4885RAB9A 3374/4885
US-20070018155-A1 New imidazole derivatives, preparation method thereof and organic electronic device using the same ICMT, TIMM9, TIMM44 ADORA2A 3155/4885NPC1 1255/4885RAB9A 1722/4885
US-20150252438-A1 AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES MECP2, MBD2, GATAD2B ADORA2A 3196/4885NPC1 4094/4885RAB9A 3374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.