SCHEMBL8931160

SCHEMBL8931160

CN(C)C(=O)c1cc(Cl)cnc1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3C3 Q8NEB9 1/20 0.50
CNR1 P21554 1/20 0.46
HPGD P15428 2/20 0.43
HTT P42858 1/20 0.43
ALDH1A1 P00352 4/20 0.42
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
MAPT P10636 1/20 0.38
CNR2 P34972 1/20 0.37
ALPL P05186 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MAP4K1 Q92918 2/20 0.36
ATF1 P18846 1/20 0.35
NFKB1 P19838 1/20 0.35
CXCR2 P25025 1/20 0.35
JAK2 O60674 1/20 0.35
CTSA P10619 1/20 0.35
NUDT1 P36639 1/20 0.35
F10 P00742 1/20 0.34
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8828399 0.84 PIK3C3 (0.49) PIK3C3CNR1HPGDHTTALDH1A1
SCHEMBL18816887 0.83 PIK3C3 (0.38) PIK3C3CNR1HPGDMEN1KMT2A
SCHEMBL8828590 0.82 PIK3C3 (0.48) PIK3C3CNR1HPGDHTTALDH1A1
SCHEMBL15999462 0.82 ALDH1A1 (0.56) PIK3C3CNR1HPGDHTTALDH1A1
SCHEMBL3279431 0.81 ALDH1A1 (0.50) CNR1HPGDALDH1A1MAPTCNR2
SCHEMBL8548977 0.80 PIK3C3 (0.46) PIK3C3CNR1HPGDHTTALDH1A1
SCHEMBL4971916 0.79 MAPK1 (0.40) PIK3C3HPGDHTTMAPTSMN1; SMN2
SCHEMBL29757489 0.79 MAPK1 (0.40) PIK3C3HPGDHTTMAPTSMN1; SMN2
SCHEMBL8828527 0.78 PIK3C3 (0.45) PIK3C3CNR1ALDH1A1KMT2AF10
SCHEMBL8931162 0.77 LMNA (0.40) PIK3C3CNR1HPGDHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-9012553-A None JP disclosed
JP-H0912553-A SUBSTITUTED PYRIDINE-BASED COMPOUND ISHIHARA SANGYO KAISHA LTD 1997-01-14 JP disclosed
EP-0388994-B1 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA (JP) 1994-10-05 EP disclosed
EP-0232067-B2 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA (JP) 1994-03-16 EP disclosed
EP-0388994-A1 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA, LTD. (JP) 1990-09-26 EP disclosed
EP-0232067-A2 Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1987-08-12 EP disclosed