Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.67 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.67 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.67 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.51 |
| ▸ | GABRP | O00591 | 2/20 | 0.51 |
| ▸ | GABRD | O14764 | 2/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.51 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.51 |
| ▸ | GABRE | P78334 | 2/20 | 0.51 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.51 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.51 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.51 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8933535 | 0.87 | CHRM1 (0.66) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL10014960 | 0.86 | GABRA1 (0.70) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL2615274 | 0.83 | GABRA1 (0.73) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL2615273 | 0.83 | GABRA1 (0.73) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL8547651 | 0.81 | GABRA1 (0.73) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL7318175 | 0.81 | GABRA1 (0.73) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL15435606 | 0.81 | GABRA1 (0.73) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL638723 | 0.81 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL31696096 | 0.81 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| N-Desalkyl-2-Oxoquazepam SCHEMBL30730010 | 0.81 | LMNA (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996023790-A1 | ACETYLIMIDAZOBENZODIAZEPINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-08-08 | — | — | WO | disclosed |
| US-4472435-A | HYPOTENSIVE AGENT, ALDOSTERONE ANTAGONIST, AND TREATMENT OF HEPATITIS | HOFFMAN-LA ROCHE INC. (US) | 1984-09-18 | — | — | US | disclosed |
| EP-0045450-B1 | BENZOPHENONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-15 | — | — | EP | disclosed |
| US-4327026-A | Benzodiazepine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1982-04-27 | — | — | US | disclosed |
| EP-0045452-A2 | Benzodiazepine derivatives, intermediates and their preparation, and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-02-10 | — | — | EP | disclosed |
| EP-0045450-A1 | Benzophenone derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-02-10 | — | — | EP | disclosed |