Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.70 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.70 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.70 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.70 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.70 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.70 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.70 |
| ▸ | GABRP | O00591 | 3/20 | 0.70 |
| ▸ | GABRD | O14764 | 3/20 | 0.70 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.70 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.70 |
| ▸ | GABRE | P78334 | 3/20 | 0.70 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.70 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.70 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.70 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10045709 | 0.89 | GABRA1 (0.72) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL9654320 | 0.88 | GABRA1 (0.66) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL8933492 | 0.86 | GABRA1 (0.67) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL16144652 | 0.83 | GABRA1 (0.77) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Delorazepam SCHEMBL157332 | 0.83 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Delorazepam SCHEMBL29375434 | 0.83 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Delorazepam SCHEMBL32681132 | 0.83 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL7720989 | 0.81 | GABRA1 (0.77) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11772087 | 0.81 | GABRA1 (0.77) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| 7-Aminoclonazepam SCHEMBL11453747 | 0.81 | GABRA1 (0.77) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083508-A1 | ALPHA-2B RECEPTOR AGONIST AND ANTICONVULSANT COMPOSITIONS FOR TREATING CHRONIC PAIN | ALLERGAN, INC. (US) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083508-A1 | ALPHA-2B RECEPTOR AGONIST AND ANTICONVULSANT COMPOSITIONS FOR TREATING CHRONIC PAIN | CNR2, OPRL1, OPRD1 | GABRA1 45/4885GABRA5 77/4885GABRA3 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.