SCHEMBL8933496

SCHEMBL8933496

CC(C)(C)c1cc(CC2SCNC2=O)c(O)c(C(C)(C)C)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.41
GAA P10253 1/20 0.41
XBP1 P17861 1/20 0.41
MAPK1 P28482 1/20 0.41
HTT P42858 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
CYP2C19 P33261 5/20 0.33
HSPA5 P11021 2/20 0.33
NR5A2 O00482 1/20 0.33
NR5A1 Q13285 1/20 0.33
CYP2C9 P11712 5/20 0.33
CYP1A2 P05177 4/20 0.33
TSHR P16473 2/20 0.33
CYP3A4 P08684 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HIF1A Q16665 1/20 0.33
PTGS2 P35354 3/20 0.32
PTGS1 P23219 3/20 0.32
CYP2D6 P10635 2/20 0.32
HSP90AA1 P07900 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tazofelone SCHEMBL380266 0.82 ALDH1A1 (0.40) ALDH1A1GAAMAPK1HTTNPSR1
Tazofelone SCHEMBL7561505 0.82 ALDH1A1 (0.40) ALDH1A1GAAMAPK1HTTNPSR1
Tazofelone SCHEMBL7562446 0.82 ALDH1A1 (0.40) ALDH1A1GAAMAPK1HTTNPSR1
SCHEMBL8933440 0.81 CA2 (0.40) ALDH1A1NPSR1PTGS2PTGS1
SCHEMBL8533710 0.79 HSPA5 (0.40) ALDH1A1GAAMAPK1HTTNPSR1
SCHEMBL8534157 0.78 MAOA (0.48) ALDH1A1GAAMAPK1HTTNPSR1
SCHEMBL8822837 0.74 GAA (0.41) ALDH1A1GAAMAPK1HTTNPSR1
SCHEMBL8537962 0.73 ESRRA (0.38) ALDH1A1HTTNPSR1CYP2C9CYP1A2
SCHEMBL8028498 0.70 HSPA5 (0.55) ALDH1A1GAAXBP1MAPK1HTT
SCHEMBL29404283 0.70 HSPA5 (0.55) ALDH1A1GAAXBP1MAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996022772-A1 METHOD FOR TREATING MULTIPLE SCLEROSIS ELI LILLY AND COMPANY (US) 1996-08-01 WO disclosed