Tazofelone

Tazofelone

SCHEMBL7562446

CC(C)(C)c1cc(C[C@@H]2SCNC2=O)cc(C(C)(C)C)c1O

nearest known ligand 0.40

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.40
MAPT P10636 5/20 0.40
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
TSHR P16473 3/20 0.40
MAPK1 P28482 3/20 0.40
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
BLM P54132 2/20 0.40
ATM Q13315 2/20 0.40
HIF1A Q16665 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
USP2 O75604 1/20 0.40
CYP2D6 P10635 1/20 0.40
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
CISD1 Q9NZ45 1/20 0.40
GAA P10253 5/20 0.40
LMNA P02545 2/20 0.40
KDM4E B2RXH2 5/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tazofelone SCHEMBL7561505 1.00 ALDH1A1 (0.40) ALDH1A1MAPTMEN1KMT2ATSHR
Tazofelone SCHEMBL380266 1.00 ALDH1A1 (0.40) ALDH1A1MAPTMEN1KMT2ATSHR
SCHEMBL8534157 0.92 MAOA (0.48) ALDH1A1MAPTMEN1KMT2ATSHR
SCHEMBL8533710 0.88 HSPA5 (0.40) ALDH1A1MAPTMEN1KMT2ATSHR
SCHEMBL8822837 0.86 GAA (0.41) ALDH1A1MAPTMEN1KMT2ATSHR
SCHEMBL8537962 0.85 ESRRA (0.38) ALDH1A1MAPTCYP1A2ATMNPSR1
SCHEMBL8933496 0.82 ALDH1A1 (0.41) ALDH1A1TSHRMAPK1CYP1A2CYP3A4
SCHEMBL8534137 0.78 THRA (0.41) MAPTMEN1KMT2AMAPK1CYP1A2
SCHEMBL8173779 0.78 CYP3A4 (0.42) MEN1KMT2ACYP3A4MAOAMAOB
SCHEMBL8933440 0.77 CA2 (0.40) ALDH1A1MEN1KMT2AATMNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0799215-B1 PROCESS FOR PREPARING BENZYL-SUBSTITUTED RHODANINE DERIVATIVES LILLY CO ELI (US) 2002-08-14 EP claimed
US-5563277-A REDUCING THIAZOLIDINONE WITH TWO MOLES OF AN ALKALI OR ALKALI-EARTH METALS IN PRESENCE OF AMMONIA OR AMINE; ANTIINFLAMMATORY AGENT ELI LILLY AND COMPANY (US) 1996-10-08 US claimed
EP-0799215-B1 PROCESS FOR PREPARING BENZYL-SUBSTITUTED RHODANINE DERIVATIVES LILLY CO ELI (US) 2002-08-14 EP disclosed
EP-0799215-A4 PROCESS FOR PREPARING BENZYL-SUBSTITUTED RHODANINE DERIVATIVES LILLY CO ELI (US) 1998-03-11 EP disclosed
EP-0799215-A1 PROCESS FOR PREPARING BENZYL-SUBSTITUTED RHODANINE DERIVATIVES ELI LILLY AND COMPANY (US) 1997-10-08 EP disclosed
US-5563277-A REDUCING THIAZOLIDINONE WITH TWO MOLES OF AN ALKALI OR ALKALI-EARTH METALS IN PRESENCE OF AMMONIA OR AMINE; ANTIINFLAMMATORY AGENT ELI LILLY AND COMPANY (US) 1996-10-08 US disclosed
WO-1996019466-A1 PROCESS FOR PREPARING BENZYL-SUBSTITUTED RHODANINE DERIVATIVES ELI LILLY AND COMPANY (US) 1996-06-27 WO disclosed