Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 8/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2190332 | 0.94 | HSP90AB1 (0.36) | ESR2HSP90AB1HDAC4HDAC2HDAC8 | |
| SCHEMBL19595794 | 0.76 | ABCC8 (0.31) | — | |
| SCHEMBL28119904 | 0.76 | NPC1 (0.33) | — | |
| SCHEMBL28299092 | 0.73 | HDAC8 (0.38) | ESR2CYP2D6HDAC4HDAC2HDAC8 | |
| SCHEMBL9730874 | 0.72 | PTGDR2 (0.33) | — | |
| SCHEMBL1116702 | 0.72 | CEL (0.34) | CYP2D6 | |
| SCHEMBL1778645 | 0.72 | KMO (0.40) | ESR2CYP2D6HDAC4HDAC2HDAC8 | |
| SCHEMBL9330891 | 0.72 | NPC1 (0.36) | — | |
| SCHEMBL434766 | 0.71 | CEL (0.36) | CYP2D6 | |
| SCHEMBL433060 | 0.71 | PTGDR2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |