Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 8/20 | 0.50 |
| ▸ | PPARD | Q03181 | 7/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935661 | 0.83 | SLC16A3 (0.46) | PPARAMAOBPPARGKMT2AIDO1 | |
| SCHEMBL883026 | 0.80 | SLC16A3 (0.55) | PPARAPPARDPPARGKMT2A | |
| SCHEMBL13042083 | 0.80 | SRD5A2 (0.43) | PPARAPPARDMAOBPPARGSRD5A2 | |
| SCHEMBL2215266 | 0.79 | RXRA (0.46) | PPARAPPARDMAOBPPARGKMT2A | |
| SCHEMBL2352150 | 0.79 | RXRA (0.46) | PPARAPPARDPPARGIDO1 | |
| SCHEMBL21991794 | 0.79 | PPARA (0.77) | PPARAPPARDMAOBPPARGFFAR1 | |
| SCHEMBL19220762 | 0.78 | IDO1 (0.59) | MAOBKMT2AIDO1 | |
| SCHEMBL13205914 | 0.78 | HDAC1 (0.41) | PPARAPPARDMAOBPPARGSRD5A2 | |
| SCHEMBL31377393 | 0.78 | NPC1 (0.53) | PPARAPPARDPPARGIDO1FFAR1 | |
| SCHEMBL2221138 | 0.78 | SLC16A3 (0.53) | PPARGIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1070487-C | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 2001-09-05 | — | — | CN | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |