Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 5/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30041447 | 0.79 | LMNA (0.60) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL28402937 | 0.79 | LMNA (0.60) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL4112701 | 0.79 | GPR84 (0.42) | SMN1; SMN2CYP1A2KDM4ETP53AR | |
| SCHEMBL8936045 | 0.77 | GRIN2D (0.46) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL13326518 | 0.74 | LMNA (0.47) | SMN1; SMN2MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL29792700 | 0.74 | LMNA (0.47) | SMN1; SMN2MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL4045859 | 0.73 | ALDH1A1 (0.59) | SMN1; SMN2MEN1KMT2ACYP1A2TSHR | |
| SCHEMBL29770446 | 0.73 | ALDH1A1 (0.59) | SMN1; SMN2MEN1KMT2ACYP1A2TSHR | |
| SCHEMBL8936178 | 0.72 | GPR17 (0.38) | SMN1; SMN2MEN1KMT2ATSHRKDM4E | |
| SCHEMBL8936157 | 0.72 | CA12 (0.44) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510338-A | ADMINISTERING TO A MAMMAL TO RELIEVE PAIN AND TO TREAT CONVULSIONS, CEREBRAL ISCHEMIC DAMAGE, AND EMESIS | GUILFORD PHARMACEUTICALS INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5342946-A | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors | GUILFORD PHARMACEUTICALS INC. (US) | 1994-08-30 | — | — | US | disclosed |