Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 9/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | G6PD | P11413 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31578887 | 0.97 | NQO2 (0.65) | NQO2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL4945159 | 0.91 | NQO2 (0.75) | NQO2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL197530 | 0.91 | NQO2 (0.75) | NQO2MAPTALDH1A1MEN1KMT2A | |
| Sulfuric Acid SCHEMBL8431344 | 0.85 | NQO2 (0.80) | NQO2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8585681 | 0.84 | NQO2 (0.46) | NQO2MAPTALDH1A1MEN1KMT2A | |
| Phenazine SCHEMBL9174820 | 0.82 | POLB (0.42) | NQO2MAPTALDH1A1MEN1KMT2A | |
| Phenazine SCHEMBL1226523 | 0.82 | POLB (0.42) | NQO2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10674809 | 0.81 | ALDH1A1 (0.43) | NQO2MAPTALDH1A1MEN1KMT2A | |
| Sulfuric Acid Dimethyl Ester SCHEMBL27551008 | 0.81 | NQO2 (0.77) | NQO2MAPTALDH1A1MEN1KMT2A | |
| Alcohol SCHEMBL27785418 | 0.80 | NQO2 (0.83) | NQO2MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0654079-A4 | A REAGENT STABILIZED BY BIVALENT METAL SALTS. | BOEHRINGER MANNHEIM CORP (US) | 1996-10-02 | — | — | EP | disclosed |
| EP-0654079-A1 | A REAGENT STABILIZED BY BIVALENT METAL SALTS | BOEHRINGER MANNHEIM CORPORATION (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994001544-A1 | A REAGENT STABILIZED BY BIVALENT METAL SALTS | BOEHRINGER MANNHEIM CORPORATION (US) | 1994-01-20 | — | — | WO | disclosed |