Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.61 |
| ▸ | MAOB | P27338 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.61 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414022 | 0.85 | MAPT (0.68) | CYP1B1MAOBMAPTLMNAALDH1A1 | |
| SCHEMBL2794365 | 0.85 | TNFRSF1A (0.53) | CYP1B1MAOBMAPTRECQLPLIN1 | |
| SCHEMBL7448677 | 0.85 | TNFRSF1A (0.53) | CYP1B1MAOBMAPTRECQLPLIN1 | |
| SCHEMBL28162352 | 0.80 | MAOB (0.47) | CYP1B1MAOBMAPTRECQLPLIN1 | |
| SCHEMBL14855431 | 0.80 | MAOB (0.61) | CYP1B1MAOBMAPTALDH1A1AKR1C1 | |
| SCHEMBL28997601 | 0.80 | TSHR (0.52) | CYP1B1MAOBMAPTRECQLPLIN1 | |
| SCHEMBL8723038 | 0.80 | MAOB (0.71) | CYP1B1MAOBMAPTBCHETNFRSF1A | |
| SCHEMBL3251236 | 0.80 | CYP1A1 (0.71) | CYP1B1MAPTLMNAALDH1A1KMT2A | |
| SCHEMBL15112053 | 0.80 | SMN1; SMN2 (0.54) | MAOBMAPTALDH1A1KMT2AMEN1 | |
| Chalcone SCHEMBL28077984 | 0.79 | CYP1B1 (0.96) | CYP1B1MAOBMAPTRECQLPLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 367 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3959208-B1 | CYCLEN BASED COMPOUNDS, COORDINATION COMPOUNDS, PEPTIDES, PHARMACEUTICAL PREPARATION, AND USE THEREOF | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2023-07-05 | — | — | EP | claimed |
| US-20220218849-A1 | CYCLEN BASED COMPOUNDS, COORDINATION COMPOUNDS, PEPTIDES, PHARMACEUTICAL PREPARATION, AND USE THEREOF | Ustav Organicke Chemie A Biochemie AV CR v.v.i. (CZ) | 2022-07-14 | — | — | US | claimed |
| EP-3362449-B1 | SIBIRILINE DERIVATIVES FOR USE FOR PREVENTING AND/OR TREATING DISORDERS ASSOCIATED WITH CELLULAR NECROPTOSIS | INST NAT SANTE RECH MED (FR) | 2021-06-16 | — | — | EP | claimed |
| CN-110709486-B | Adhesive articles and methods of making and using the same | 3M创新有限公司 | 2021-04-16 | — | — | CN | claimed |
| WO-2020259726-A1 | CYCLEN BASED COMPOUNDS, COORDINATION COMPOUNDS, PEPTIDES, PHARMACEUTICAL PREPARATION, AND USE THEREOF | Ustav Organicke Chemie A Biochemie AV CR v.v.i. (CZ) | 2020-12-30 | — | — | WO | claimed |
| EP-3757098-A1 | CYCLEN BASED COMPOUNDS, COORDINATION COMPOUNDS, PEPTIDES, PHARMACEUTICAL PREPARATION, AND USE THEREOF | Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) | 2020-12-30 | — | — | EP | claimed |
| US-10426758-B2 | Sibiriline derivatives for use for preventing and/or treating disorders associated with cellular necroptosis | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2019-10-01 | — | — | US | claimed |
| US-20180325876-A1 | Sibiriline Derivatives For Use For Preventing And/Or Treating Disorders Associated With Cellular Necroptosis | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2018-11-15 | — | — | US | claimed |
| EP-3362449-A1 | SIBIRILINE DERIVATIVES FOR USE FOR PREVENTING AND/OR TREATING DISORDERS ASSOCIATED WITH CELLULAR NECROPTOSIS | Institut National de la Sante et de la Recherche Medicale (INSERM) (FR) | 2018-08-22 | — | — | EP | claimed |
| CN-105949141-B | A kind of method for preparing SC 69124 intermediate | 姚美艳 | 2018-07-03 | — | — | CN | claimed |
| EP-0246982-B1 | TRIAZOLE OR IMIDAZOLE AND TETRAHYDROFURAN COMPOUNDS, THEIR USE AS FUNGICIDES AND PREPARATION PROCESSES | RHONE-POULENC AGROCHIMIE (FR) | 1993-02-03 | — | — | EP | claimed |
| EP-0279239-B1 | MICROBICIDES | CIBA-GEIGY AG (CH) | 1992-11-11 | — | — | EP | claimed |
| WO-1992014736-A1 | HERBICIDAL PYRONES | DUNLENA PTY. LIMITED (AU) | 1992-09-03 | — | — | WO | claimed |
| EP-0279239-A1 | Microbicides | CIBA-GEIGY AG (CH) | 1988-08-24 | — | — | EP | claimed |
| US-4617401-A | ANTISPASMODIC AGENTS, VASODILATORS | SUNTORY LTD. (JP) | 1986-10-14 | — | — | US | claimed |
| EP-0039903-B1 | 8-SUBSTITUTED PYRROLIZIDINES AND QUATERNARY AMMONIUM SALTS THEREOF | SUNTORY KABUSHIKI KAISHA (JP) | 1986-04-09 | — | — | EP | claimed |
| EP-0039903-A2 | 8-Substituted pyrrolizidines and quaternary ammonium salts thereof | SUNTORY KABUSHIKI KAISHA (JP) | 1981-11-18 | — | — | EP | claimed |
| US-4103086-A | 8-Oxo-4-thia-1-azabicyclo (4.2.0)-oct-2-ene derivatives | SMITHKLINE CORPORATION (US) | 1978-07-25 | — | — | US | claimed |
| US-4000154-A | 3-Substituted-6β-(amino- and acylamino)-7-oxo-1,3-diazabicyclo[3.2.0]-h | SMITHKLINE CORPORATION (US) | 1976-12-28 | — | — | US | claimed |
| US-3936447-A | 7-Acylamino-desacetoxy-cephalosporanic acid esters and their production | BAYER AKTIENGESELLSCHAFT (DT) | 1976-02-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180325876-A1 | Sibiriline Derivatives For Use For Preventing And/Or Treating Disorders Associated With Cellular Necroptosis | RIPK3, MLKL, PARK7 | CYP1B1 4630/4885MAOB 2412/4885MAPT 285/4885 |
| US-20220218849-A1 | CYCLEN BASED COMPOUNDS, COORDINATION COMPOUNDS, PEPTIDES, PHARMACEUTICAL PREPARATION, AND USE THEREOF | CCNY, CCNC, CPN1 | CYP1B1 1780/4885MAOB 2855/4885MAPT 4532/4885 |
| US-10426758-B2 | Sibiriline derivatives for use for preventing and/or treating disorders associated with cellular necroptosis | RIPK3, MLKL, PARK7 | CYP1B1 4630/4885MAOB 2412/4885MAPT 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.