SCHEMBL8937584

SCHEMBL8937584

O=C(O)c1ccn(O)c1-c1cccs1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.48
KMT2A Q03164 5/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
PTPN1 P18031 1/20 0.42
MEN1 O00255 4/20 0.42
RXFP1 Q9HBX9 2/20 0.42
PRNP P04156 1/20 0.42
PPARG P37231 1/20 0.42
NCOR2 Q9Y618 1/20 0.42
DAO P14920 1/20 0.40
LMNA P02545 1/20 0.40
ALOX15 P16050 1/20 0.40
MAPK1 P28482 1/20 0.39
ALDH1A1 P00352 2/20 0.39
GAA P10253 2/20 0.39
TP53 P04637 1/20 0.39
GLA P06280 1/20 0.39
HPGD P15428 1/20 0.39
CASP1 P29466 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8937621 0.81 KDM4E (0.47) KDM4EKMT2AL3MBTL1TDP1PTPN1
SCHEMBL27991328 0.71 KDM4E (0.56) KDM4EKMT2AL3MBTL1PTPN1MEN1
SCHEMBL1823757 0.69 GPR35 (0.52) KDM4EKMT2APTPN1MEN1RXFP1
SCHEMBL9192321 0.68 KDM4E (0.49) KDM4EKMT2AL3MBTL1TDP1PTPN1
SCHEMBL12279980 0.68 GPR35 (0.51) KDM4EKMT2APTPN1MEN1RXFP1
SCHEMBL932848 0.68 ALOX15 (0.53) KDM4EKMT2AL3MBTL1PTPN1MEN1
Hydrochloric Acid SCHEMBL1825977 0.68 GPR35 (0.51) KDM4EKMT2APTPN1MEN1RXFP1
SCHEMBL3494494 0.68 POLB (0.50) KDM4EL3MBTL1TDP1MAPK1ALDH1A1
SCHEMBL4461418 0.66 KDM4E (0.74) KDM4EKMT2ATDP1MEN1RXFP1
SCHEMBL8937581 0.66 KDM4E (0.44) KDM4EKMT2AL3MBTL1TDP1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5563166-A Thienyl- and furylpyrrole fungicidal agents AMERICAN CYANAMID CO. (US) 1996-10-08 US disclosed
US-5492925-A PROTECTING PLANTS AMERICAN CYANAMID COMPANY (US) 1996-02-20 US disclosed
US-5480902-A Thienylpyrrole fungicidal agents AMERICAN CYANAMID COMPANY (US) 1996-01-02 US disclosed
EP-0641794-A1 Thienyl- and furylpyrrole derivatives, their preparation and their use as insecticides and acaricides AMERICAN CYANAMID COMPANY (US) 1995-03-08 EP disclosed