Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938249 | 0.90 | MAP2 (0.60) | MAP2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL9034407 | 0.84 | ALDH1A1 (0.64) | MAP2ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL8938321 | 0.83 | PTGS2 (0.52) | MAP2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL8938413 | 0.79 | CNR1 (0.45) | ALDH1A1KDM4EPOLBPTGS2 | |
| SCHEMBL9033744 | 0.77 | MAPK3 (0.43) | MAP2ALDH1A1KDM4EPOLBPTGS2 | |
| SCHEMBL9040770 | 0.76 | MCL1 (0.44) | MAP2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL9032423 | 0.75 | PTGS2 (0.50) | MAP2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL8938478 | 0.75 | PTGS2 (0.42) | MAP2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL6921821 | 0.74 | MAP2 (0.65) | MAP2ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL42364 | 0.73 | MAP2 (1.00) | MAP2ALDH1A1KDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527819-A | TREATING AIDS | MERCK & CO., INC. (US) | 1996-06-18 | — | — | US | disclosed |
| EP-0686148-A4 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO INC (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0686148-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO. INC. (US) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019321-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |