Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 6/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938413 | 0.90 | CNR1 (0.45) | MAPK3MAPK1CNR1PTGS2KDM4E | |
| SCHEMBL8938478 | 0.81 | PTGS2 (0.42) | CNR1PTGS2KDM4EALDH1A1POLB | |
| SCHEMBL8938242 | 0.79 | TUBB4A (0.46) | MAPK3MAPK1CNR1PTGS2KDM4E | |
| SCHEMBL9032423 | 0.79 | PTGS2 (0.50) | CNR1PTGS2KDM4EALDH1A1PPARG | |
| SCHEMBL9040770 | 0.78 | MCL1 (0.44) | CNR1PTGS2KDM4EALDH1A1POLB | |
| SCHEMBL8938342 | 0.77 | MAP2 (0.58) | PTGS2KDM4EALDH1A1POLBMAP2 | |
| SCHEMBL8938321 | 0.75 | PTGS2 (0.52) | CNR1PTGS2KDM4EALDH1A1POLB | |
| SCHEMBL8938249 | 0.75 | MAP2 (0.60) | MAPK1KDM4EALDH1A1POLBMAP2 | |
| SCHEMBL9034407 | 0.72 | ALDH1A1 (0.64) | PTGS2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8938394 | 0.70 | TUBB4A (0.45) | CNR1PTGS2KDM4EALDH1A1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686148-A4 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO INC (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0686148-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO. INC. (US) | 1995-12-13 | — | — | EP | disclosed |