Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938319 | 0.91 | SLC6A4 (0.43) | KCNH2SLC6A3SLC6A4SLC6A2DRD2 | |
| Fumaric Acid SCHEMBL8938229 | 0.85 | SLC6A4 (0.44) | KCNH2SLC6A3SLC6A4SLC6A2DRD2 | |
| SCHEMBL8938462 | 0.82 | KCNH2 (0.44) | KCNH2SLC6A3SLC6A4SLC6A2ADRA1A | |
| SCHEMBL8938383 | 0.81 | DRD2 (0.36) | KCNH2SLC6A3SLC6A2DRD2DRD3 | |
| SCHEMBL8938436 | 0.75 | HRH3 (0.55) | MEN1KMT2A | |
| Zamifenacin SCHEMBL311829 | 0.72 | ADRA1D (0.46) | SLC6A3SLC6A4SLC6A2ADRA1AOPRM1 | |
| Zamifenacin SCHEMBL1933745 | 0.72 | ADRA1D (0.46) | SLC6A3SLC6A4SLC6A2ADRA1AOPRM1 | |
| Zamifenacin SCHEMBL4603503 | 0.72 | ADRA1D (0.46) | SLC6A3SLC6A4SLC6A2ADRA1AOPRM1 | |
| SCHEMBL8938323 | 0.72 | CHRM1 (0.36) | KCNH2SLC6A3SLC6A4SLC6A2DRD2 | |
| Zamifenacin SCHEMBL13957195 | 0.71 | SLC6A2 (0.41) | KCNH2SLC6A3SLC6A4SLC6A2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534626-A | SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST INTERMEDIATES | PFIZER INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5410046-A | Selective muscarinic receptor antagonists | PFIZER INC. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5231104-A | Anticholinergic | PFIZER INC. (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0350309-B1 | PIPERIDINE DERIVATIVES | Pfizer Limited (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089505-A | Anticholinergic agents | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0350309-A1 | Piperidine derivatives | Pfizer Limited (GB) | 1990-01-10 | — | — | EP | disclosed |