Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zamifenacin SCHEMBL1933745 | 0.90 | ADRA1D (0.46) | SLC6A2SLC6A4SLC6A3ADRA1DADRA1A | |
| Zamifenacin SCHEMBL311829 | 0.90 | ADRA1D (0.46) | SLC6A2SLC6A4SLC6A3ADRA1DADRA1A | |
| Zamifenacin SCHEMBL4603503 | 0.89 | ADRA1D (0.46) | SLC6A2SLC6A4SLC6A3ADRA1DADRA1A | |
| Zamifenacin SCHEMBL13957200 | 0.85 | NOS2 (0.41) | ADRA1DADRA1AADRA1BKDM4ENOS2 | |
| Zamifenacin SCHEMBL3227612 | 0.83 | KDM4E (0.45) | ADRA1DADRA1AADRA1BKDM4ELMNA | |
| Zamifenacin SCHEMBL8938193 | 0.83 | KDM4E (0.45) | ADRA1DADRA1AADRA1BKDM4ELMNA | |
| Zamifenacin SCHEMBL13957196 | 0.82 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BKDM4ENOS2 | |
| Zamifenacin SCHEMBL13957310 | 0.82 | SLC6A2 (0.41) | KCNH2SLC6A2SLC6A4SLC6A3ADRA1D | |
| Zamifenacin SCHEMBL13957195 | 0.82 | SLC6A2 (0.41) | KCNH2SLC6A2SLC6A4SLC6A3ADRA1D | |
| SCHEMBL8938382 | 0.82 | KCNH2 (0.41) | KCNH2SLC6A2SLC6A4SLC6A3ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534626-A | SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST INTERMEDIATES | PFIZER INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5410046-A | Selective muscarinic receptor antagonists | PFIZER INC. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5231104-A | Anticholinergic | PFIZER INC. (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0350309-B1 | PIPERIDINE DERIVATIVES | Pfizer Limited (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089505-A | Anticholinergic agents | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0350309-A1 | Piperidine derivatives | Pfizer Limited (GB) | 1990-01-10 | — | — | EP | disclosed |