Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.43 |
| ▸ | RXRB | P28702 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938549 | 0.91 | AKR1B1 (0.44) | AKR1B1CA2POLBHSD17B10KDM4E | |
| SCHEMBL9327652 | 0.85 | CTNNB1 (0.55) | AKR1B1POLBHSD17B10HPGDCTNNB1 | |
| SCHEMBL11694491 | 0.81 | AKR1B1 (0.46) | AKR1B1CA2POLBHSD17B10KDM4E | |
| SCHEMBL1403662 | 0.78 | FABP4 (0.56) | AKR1B1CA2POLBMAPTFABP4 | |
| SCHEMBL28840819 | 0.76 | AKR1B1 (0.47) | AKR1B1RXRBRXRARXRGCA2 | |
| SCHEMBL3838996 | 0.76 | RXRB (0.62) | AKR1B1RXRBRXRARXRGPOLB | |
| SCHEMBL5527444 | 0.74 | RXRB (0.65) | AKR1B1RXRBRXRARXRGPOLB | |
| SCHEMBL19996854 | 0.74 | RXRB (0.60) | AKR1B1RXRBRXRARXRGPOLB | |
| Formic Acid SCHEMBL28322635 | 0.73 | RAB9A (0.54) | AKR1B1POLBMAPTFABP4RAB9A | |
| SCHEMBL3706366 | 0.73 | ACACB (0.33) | POLBCTNNB1WNT3ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534626-A | SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST INTERMEDIATES | PFIZER INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5410046-A | Selective muscarinic receptor antagonists | PFIZER INC. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5241044-A | Soluble poly(p-phenylene)s | EDISON POLYMER INNOVATION CORPORATION (US) | 1993-08-31 | — | — | US | disclosed |
| US-5231104-A | Anticholinergic | PFIZER INC. (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0350309-B1 | PIPERIDINE DERIVATIVES | Pfizer Limited (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089505-A | Anticholinergic agents | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0350309-A1 | Piperidine derivatives | Pfizer Limited (GB) | 1990-01-10 | — | — | EP | disclosed |