Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.41 |
| ▸ | CCR3 | P51677 | 6/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937216 | 0.96 | HRH1 (0.42) | HRH1CCR3MAOAMAOBSCN1A | |
| SCHEMBL8938967 | 0.91 | HRH1 (0.44) | HRH1CCR3MAOAMAOBSCN1A | |
| SCHEMBL8937220 | 0.89 | HRH1 (0.39) | HRH1CCR3MAOAMAOBSCN1A | |
| SCHEMBL8937204 | 0.89 | MAOA (0.49) | HRH1CCR3MAOAMAOBSCN1A | |
| SCHEMBL8936704 | 0.89 | HRH1 (0.45) | HRH1CCR3MAOAMAOBKCNH2 | |
| SCHEMBL13890296 | 0.88 | ACHE (0.42) | HRH1CCR3MAOAMAOBSCN1A | |
| SCHEMBL8939080 | 0.84 | HRH1 (0.39) | HRH1CCR3MAOAMAOBSCN1A | |
| SCHEMBL8937187 | 0.82 | HRH1 (0.39) | HRH1CCR3KCNH2 | |
| SCHEMBL8937219 | 0.82 | OPRM1 (0.41) | HRH1CCR3SCN1ASCN8AMEN1 | |
| SCHEMBL8937227 | 0.82 | ACHE (0.43) | CCR3SCN1ASCN8AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |