Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | GFER | P55789 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939613 | 0.87 | KMT2A (0.56) | ALDH1A1SMN1; SMN2GAAGFERKMT2A | |
| SCHEMBL8939653 | 0.85 | HSD11B1 (0.47) | ALDH1A1SMN1; SMN2GAAGFERKMT2A | |
| SCHEMBL8939649 | 0.78 | TSHR (0.57) | ALDH1A1SMN1; SMN2GAAGFERKMT2A | |
| SCHEMBL9125939 | 0.77 | TYR (0.60) | ALDH1A1SMN1; SMN2GAAKMT2ALMNA | |
| SCHEMBL2950399 | 0.77 | SMN1; SMN2 (0.74) | ALDH1A1SMN1; SMN2GAAGFERKMT2A | |
| SCHEMBL9126525 | 0.76 | KDM4E (0.59) | ALDH1A1SMN1; SMN2GAAKMT2ALMNA | |
| SCHEMBL8939721 | 0.75 | HSD11B1 (0.44) | ALDH1A1SMN1; SMN2KMT2ALMNAPOLB | |
| SCHEMBL9720759 | 0.71 | HTR1A (0.54) | ALDH1A1SMN1; SMN2GAAKMT2ALMNA | |
| SCHEMBL2966619 | 0.71 | GAA (0.71) | ALDH1A1SMN1; SMN2GAAGFERKMT2A | |
| SCHEMBL2155668 | 0.71 | GAA (0.71) | ALDH1A1SMN1; SMN2GAAGFERKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626369-B1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1996-09-18 | — | — | EP | disclosed |
| US-5523464-A | BONE DISORDERS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| EP-0626369-A1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-30 | — | — | EP | disclosed |