Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LIG1 | P18858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939743 | 0.81 | MAPT (0.49) | MAPK1HTR1ASLC6A4ADRA1AMAPT | |
| SCHEMBL8939785 | 0.80 | HTR1A (0.42) | HPGDTSHRMAPK1HSD17B10MEN1 | |
| SCHEMBL27982817 | 0.80 | TSHR (0.41) | HPGDTSHRMAPK1HSD17B10LIG1 | |
| SCHEMBL8939792 | 0.76 | CYP1A2 (0.46) | HPGDTSHRLMNACYP1A2CYP3A4 | |
| SCHEMBL8859963 | 0.76 | LTA4H (0.44) | HPGDMEN1KMT2AHTR1ACYP2D6 | |
| SCHEMBL3849532 | 0.74 | HPGD (0.44) | HPGDTSHRMAPK1HSD17B10LIG1 | |
| SCHEMBL7687255 | 0.73 | HTR2A (0.37) | HPGDMEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL5889093 | 0.73 | HPGD (0.44) | HPGDTSHRMAPK1HSD17B10LIG1 | |
| SCHEMBL15068016 | 0.72 | TSHR (0.42) | HPGDTSHRMAPK1HSD17B10LIG1 | |
| SCHEMBL15068002 | 0.72 | ALDH1A1 (0.43) | HPGDTSHRMAPK1HSD17B10LIG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |