Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746382 | 1.00 | TDP1 (0.40) | TDP1L3MBTL1BCHEHPGDSIGMAR1 | |
| SCHEMBL7429582 | 0.98 | BCHE (0.40) | BCHEHPGD | |
| SCHEMBL7746427 | 0.95 | HTR2A (0.42) | HPGD | |
| SCHEMBL6160386 | 0.89 | ABCB1 (0.44) | — | |
| SCHEMBL8939736 | 0.85 | TUBB4A (0.50) | TDP1L3MBTL1 | |
| SCHEMBL8939791 | 0.84 | APP (0.38) | — | |
| SCHEMBL8827586 | 0.84 | HTR7 (0.40) | — | |
| SCHEMBL8939769 | 0.81 | LTA4H (0.42) | HPGD | |
| SCHEMBL8939724 | 0.77 | MAOB (0.44) | — | |
| SCHEMBL7746343 | 0.76 | TNKS2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |