Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13098131 | 0.89 | TRPA1 (0.51) | TRPA1HSD17B10ALOX15KDM4EPOLB | |
| SCHEMBL13098116 | 0.89 | TRPA1 (0.54) | TRPA1HSD17B10ALOX15KDM4EPOLB | |
| SCHEMBL11855241 | 0.82 | TRPA1 (0.60) | TRPA1HSD17B10ALOX15KDM4EPOLB | |
| SCHEMBL13098112 | 0.81 | TRPA1 (0.60) | TRPA1HSD17B10ALOX15KDM4EPOLB | |
| SCHEMBL6095089 | 0.76 | TRPA1 (0.48) | TRPA1HSD17B10ALOX15KDM4EPOLB | |
| SCHEMBL9486 | 0.75 | TRPA1 (0.57) | TRPA1HSD17B10KDM4EPOLBATM | |
| Hydrochloric Acid SCHEMBL6093232 | 0.75 | TRPA1 (0.47) | TRPA1HSD17B10ALOX15KDM4EPOLB | |
| Hydrochloric Acid SCHEMBL29877364 | 0.75 | TRPA1 (0.47) | TRPA1HSD17B10ALOX15KDM4EPOLB | |
| SCHEMBL11151970 | 0.75 | ALOX5 (0.52) | TRPA1HSD17B10KDM4EPOLBATM | |
| SCHEMBL13098115 | 0.75 | ALOX5 (0.55) | TRPA1HSD17B10KDM4EPOLBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190038573-A1 | ION CHANNEL ACTIVATORS AND METHODS OF USE | CLIFF-CARTWRIGHT CORPORATION | 2019-02-07 | — | — | US | disclosed |
| US-20170042834-A1 | ION CHANNEL ACTIVATORS AND METHODS OF USE | CLIFF-CARTWRIGHT CORPORATION | 2017-02-16 | — | — | US | disclosed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| US-8461145-B2 | Dibenzoazepine and dibenzooxazepine TRPA1 agonists | JANSSEN PHARMACEUTICA NV (BE) | 2013-06-11 | — | — | US | disclosed |
| US-8461145-B2 | Dibenzoazepine and dibenzooxazepine TRPA1 agonists | JANSSEN PHARMACEUTICA NV (BE) | 2013-06-11 | — | — | US | disclosed |
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
| US-20110124666-A1 | 3,4-DIHYDROPYRIMIDINE TRPA1 ANTAGONISTS | Janssen Pharmaceutica NV a corporation | 2011-05-26 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |
| US-20100273773-A1 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | US | disclosed |
| US-20100273773-A1 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | US | disclosed |
| WO-2009147079-A1 | 3,4-DIHYDROPYRIMIDINE TRPA1 ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009071631-A2 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124666-A1 | 3,4-DIHYDROPYRIMIDINE TRPA1 ANTAGONISTS | TRPA1, TRPV1, TRPV3 | TRPA1 1/4885HSD17B10 3134/4885ALOX15 710/4885 |
| US-20100273773-A1 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885HSD17B10 1768/4885ALOX15 83/4885 |
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885HSD17B10 3348/4885ALOX15 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.