Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.48 |
| ▸ | PPARA | Q07869 | 8/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941430 | 0.92 | ALOX5 (0.51) | PPARGPPARAALOX5EPHX2 | |
| SCHEMBL8941351 | 0.88 | PPARG (0.48) | PPARGPPARATSHRNPC1RAB9A | |
| SCHEMBL8941319 | 0.83 | PPARG (0.50) | PPARGPPARATSHRNPC1RAB9A | |
| SCHEMBL8941404 | 0.82 | ALOX5 (0.54) | PPARGPPARAALOX5EPHX2 | |
| SCHEMBL4729578 | 0.80 | ALOX5 (0.44) | ALOX5EPHX2NPC1RAB9ALMNA | |
| SCHEMBL8941364 | 0.80 | PPARG (0.47) | PPARGPPARAALOX5TSHRNPC1 | |
| SCHEMBL5086216 | 0.80 | ALOX5 (0.44) | ALOX5EPHX2NPC1RAB9ALMNA | |
| SCHEMBL8941453 | 0.78 | PPARG (0.48) | PPARGPPARAALOX5TSHRNPC1 | |
| SCHEMBL8941743 | 0.78 | PPARG (0.48) | PPARGPPARAALOX5TSHRNPC1 | |
| SCHEMBL8941448 | 0.78 | PPARG (0.48) | PPARGPPARAALOX5TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552424-A | Isoxazolines as antiinflammatory agents | PFIZER INC. (US) | 1996-09-03 | — | — | US | disclosed |