Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.47 |
| ▸ | PPARA | Q07869 | 8/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941351 | 0.92 | PPARG (0.48) | PPARGPPARALMNATSHRNPC1 | |
| SCHEMBL8941430 | 0.88 | ALOX5 (0.51) | PPARGPPARAALOX5PTPN1FAAH | |
| SCHEMBL8941348 | 0.80 | PPARG (0.48) | PPARGPPARAALOX5LMNATSHR | |
| SCHEMBL8609409 | 0.80 | NPC1 (0.45) | ALOX5LMNATSHRNPC1RAB9A | |
| SCHEMBL4729170 | 0.80 | NPC1 (0.45) | ALOX5LMNATSHRNPC1RAB9A | |
| SCHEMBL4729172 | 0.80 | NPC1 (0.45) | ALOX5LMNATSHRNPC1RAB9A | |
| SCHEMBL8941436 | 0.75 | PPARG (0.47) | PPARGPPARAALOX5CA1CA2 | |
| SCHEMBL8941747 | 0.75 | ALOX5 (0.53) | PPARGPPARAALOX5 | |
| SCHEMBL8655026 | 0.75 | MAPT (0.48) | ALOX5NPC1RAB9AALDH1A1 | |
| SCHEMBL8656547 | 0.75 | MAPT (0.48) | ALOX5NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552424-A | Isoxazolines as antiinflammatory agents | PFIZER INC. (US) | 1996-09-03 | — | — | US | disclosed |