Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941426 | 0.81 | ALOX5 (0.54) | PPARGPPARA | |
| SCHEMBL8941431 | 0.77 | PPARG (0.39) | PPARGPPARAATMMIFAPAF1 | |
| SCHEMBL9265050 | 0.72 | ATM (0.49) | PPARGPPARAATMMAOBAPAF1 | |
| SCHEMBL8941404 | 0.72 | ALOX5 (0.54) | PPARGPPARA | |
| SCHEMBL8941462 | 0.69 | PPARG (0.44) | PPARGPPARAATMMAOBAPAF1 | |
| SCHEMBL8941375 | 0.69 | ALOX5 (0.46) | PPARGPPARAATMAPAF1POLB | |
| SCHEMBL8941319 | 0.68 | PPARG (0.50) | PPARGPPARAATMNPC1RAB9A | |
| SCHEMBL8941419 | 0.67 | ALOX5 (0.63) | PPARGPPARALMNATSHR | |
| SCHEMBL8941589 | 0.67 | PPARG (0.49) | PPARGPPARAATMNPC1RAB9A | |
| SCHEMBL8941747 | 0.66 | ALOX5 (0.53) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552424-A | Isoxazolines as antiinflammatory agents | PFIZER INC. (US) | 1996-09-03 | — | — | US | disclosed |