Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941426 | 0.82 | ALOX5 (0.54) | PPARGPPARAALOX5 | |
| SCHEMBL8941375 | 0.76 | ALOX5 (0.46) | PPARGPPARAAPAF1POLBGRK2 | |
| SCHEMBL8941404 | 0.75 | ALOX5 (0.54) | PPARGPPARAALOX5 | |
| SCHEMBL8941438 | 0.74 | POLB (0.50) | APAF1POLBGRK2APOBEC3GRAB9A | |
| SCHEMBL8941411 | 0.73 | PPARG (0.43) | PPARGPPARAAPAF1POLBGRK2 | |
| SCHEMBL9265050 | 0.71 | ATM (0.49) | PPARGPPARAAPAF1POLBGRK2 | |
| SCHEMBL8941475 | 0.69 | PPARG (0.41) | PPARGPPARAAPAF1POLBGRK2 | |
| SCHEMBL8941747 | 0.69 | ALOX5 (0.53) | PPARGPPARAALOX5 | |
| SCHEMBL9473434 | 0.67 | ALOX5 (0.71) | ALOX5 | |
| SCHEMBL8941395 | 0.67 | POLB (0.52) | APAF1POLBGRK2APOBEC3GALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552424-A | Isoxazolines as antiinflammatory agents | PFIZER INC. (US) | 1996-09-03 | — | — | US | disclosed |