Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210989 | 0.85 | LMNA (0.36) | ALDH1A1TSHRMAPK1MAPT | |
| SCHEMBL13185549 | 0.82 | ALDH1A1 (0.43) | ALDH1A1CYP3A4MAPTSRD5A1SRD5A2 | |
| SCHEMBL9390090 | 0.81 | NLRP3 (0.39) | ALDH1A1APPMAPTHTTHSD17B10 | |
| SCHEMBL7565934 | 0.78 | ALDH1A1 (0.42) | ALDH1A1CYP3A4MAPTSRD5A1SRD5A2 | |
| SCHEMBL7958551 | 0.78 | ALDH1A1 (0.42) | ALDH1A1CYP3A4MAPTSRD5A1SRD5A2 | |
| SCHEMBL7571641 | 0.77 | NLRP3 (0.41) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9391452 | 0.77 | NLRP3 (0.41) | ALDH1A1APPHTTMEN1KMT2A | |
| SCHEMBL6580559 | 0.75 | ALDH1A1 (0.45) | ALDH1A1CYP3A4TSHRAPPPSEN1 | |
| SCHEMBL4911889 | 0.75 | OPRM1 (0.42) | CYP3A4TSHR | |
| SCHEMBL10998258 | 0.74 | KDM1A (0.46) | ALDH1A1MAPTPARP1HSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2495245-A2 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | FOB Synthesis, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20100075945-A1 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | CHOI WOO-BAEG | 2010-03-25 | — | — | US | disclosed |
| US-20100075945-A1 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | CHOI WOO-BAEG | 2010-03-25 | — | — | US | disclosed |
| US-7632828-B2 | Gram-positive carbapenem antibacterials and processes for their preparation | FOB SYNTHESIS, INC. (US) | 2009-12-15 | — | — | US | disclosed |
| US-7632828-B2 | Gram-positive carbapenem antibacterials and processes for their preparation | FOB SYNTHESIS, INC. (US) | 2009-12-15 | — | — | US | disclosed |
| US-5480913-A | DIHYDRO-PHENANTHRENE DERIVATIVES, SIDE EFFECT REDUCTION | ARCH DEVELOPMENT CORPORATION (US) | 1996-01-02 | — | — | US | disclosed |
| EP-0363128-B1 | ANTI-ANDROGEN COMPOUNDS | ARCH DEVELOPMENT CORPORATION (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5208263-A | Dihydrophenanthrene derivatives | ARCH DEVELOPMENT CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |
| WO-1990003979-A2 | ANTI-ANDROGEN COMPOUNDS | ARCH DEVELOPMENT CORPORATION (US) | 1990-04-19 | — | — | WO | disclosed |
| EP-0363128-A2 | Anti-androgen compounds | ARCH DEVELOPMENT CORPORATION (US) | 1990-04-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075945-A1 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | MGAM, GSK3B, GSK3A | ALDH1A1 3694/4885CYP3A4 1448/4885TSHR 4841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.