Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29590036 | 1.00 | PNMT (0.67) | PNMTADRA2A | |
| SCHEMBL894205 | 1.00 | PNMT (0.67) | PNMTADRA2A | |
| SCHEMBL29570471 | 1.00 | PNMT (0.67) | PNMTADRA2A | |
| SCHEMBL29743356 | 1.00 | PNMT (0.67) | PNMTADRA2A | |
| SCHEMBL4738129 | 1.00 | PNMT (0.67) | PNMTADRA2A | |
| Hydrochloric Acid SCHEMBL7478887 | 0.98 | PNMT (0.65) | PNMTADRA2A | |
| Hydrochloric Acid SCHEMBL7478882 | 0.98 | PNMT (0.65) | PNMTADRA2A | |
| SCHEMBL8783405 | 0.85 | PNMT (0.64) | PNMT | |
| SCHEMBL11388285 | 0.85 | PNMT (0.64) | PNMT | |
| SCHEMBL8853554 | 0.83 | PNMT (0.71) | PNMTADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 169 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586170-B | Indolinyl acyl derivative and synthetic method of isoquinoline formyl derivative | 江苏集萃分子工程研究院有限公司 | 2024-04-09 | — | — | CN | claimed |
| CN-117586170-A | Indolinyl acyl derivative and synthetic method of isoquinoline formyl derivative | 江苏集萃分子工程研究院有限公司 | 2024-02-23 | — | — | CN | claimed |
| EP-0691128-B1 | Use of CRF antagonists | PFIZER (US) | 2002-12-11 | — | — | EP | claimed |
| US-6469041-B2 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-10-22 | — | — | US | claimed |
| US-20020042422-A1 | Certain pyrazole derivatives as corticotropin-releasing factor CRF1 ligands | NEUROGEN CORPORATION | 2002-04-11 | — | — | US | claimed |
| US-6200979-B1 | ADMINISTERING SUBSTITUTED PYRAZOLES AND PYZAZOLOPYRIMIDINES FOR TREATING PHOBIAS OBSESSIVE-COMPULSIVE DISORDER, POST-TRAUMATIC STRESS DISORDER, SINGLE EPISODE DEPRESSION, RECURRENT DEPRESSION, DYSTHYMIA, BIPOLAR DISORDERS | BRIGHT GENE M (US) | 2001-03-13 | — | — | US | claimed |
| EP-0674631-B1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER (US) | 1999-12-08 | — | — | EP | claimed |
| EP-0959074-A2 | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1999-11-24 | — | — | EP | claimed |
| EP-0941223-A1 | CERTAIN PYRAZOLE DERIVATIVES AS CORTICOTROPIN-RELEASING FACTOR RECEPTOR CRF1 SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-09-15 | — | — | EP | claimed |
| US-5760225-A | DIAGNOSIS AND TREATMENT OF STRESS DISORDERS AND DEPRESSION | NEUROGEN CORPORATION (US) | 1998-06-02 | — | — | US | claimed |
| WO-1998021200-A1 | CERTAIN PYRAZOLE DERIVATIVES AS CORTICOTROPIN-RELEASING FACTOR RECEPTOR CRF1 SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-05-22 | — | — | WO | claimed |
| US-5705646-A | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1998-01-06 | — | — | US | claimed |
| EP-0674625-B1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER (US) | 1997-12-10 | — | — | EP | claimed |
| EP-0764153-A1 | SUBSTITUTED PYRAZOLES HAVING CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1997-03-26 | — | — | EP | claimed |
| EP-0691128-A1 | Methods of administering CRF antagonists | PFIZER INC. (US) | 1996-01-10 | — | — | EP | claimed |
| WO-1995033727-A1 | SUBSTITUTED PYRAZOLES HAVING CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1995-12-14 | — | — | WO | claimed |
| EP-0674625-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1995-10-04 | — | — | EP | claimed |
| EP-0674631-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | claimed |
| WO-1994013661-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | claimed |
| WO-1994013644-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1994-06-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042422-A1 | Certain pyrazole derivatives as corticotropin-releasing factor CRF1 ligands | CRH, CRHR1, CRHR2 | PNMT 1817/4885ADRA2A 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.