Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782862 | 0.84 | KCNA3 (0.45) | ALOX5IRAK4PARP1BRD4KCNA3 | |
| SCHEMBL8942318 | 0.82 | ALOX5 (0.52) | ALOX5BRD4LTB4RLTB4R2BCAT2 | |
| SCHEMBL8942395 | 0.80 | ALOX5 (0.47) | ALOX5LTB4RLTB4R2ALDH1A1FFAR1 | |
| SCHEMBL8942399 | 0.80 | CTNNB1 (0.52) | MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL28306143 | 0.74 | IRAK4 (0.70) | ALOX5IRAK4PARP1LTB4RLTB4R2 | |
| SCHEMBL28325904 | 0.74 | IRAK4 (0.70) | ALOX5IRAK4PARP1LTB4RLTB4R2 | |
| SCHEMBL312798 | 0.71 | KDM4E (0.54) | IRAK4LTB4RLTB4R2RORCMEN1 | |
| SCHEMBL8783572 | 0.71 | ALOX5 (0.42) | ALOX5BRD4LTB4RLTB4R2RORC | |
| SCHEMBL8782774 | 0.70 | ALOX5 (0.55) | ALOX5BRD4LTB4RLTB4R2KMT2A | |
| SCHEMBL10408836 | 0.70 | KDM4E (0.53) | IRAK4LTB4RLTB4R2RORCMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |