Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944168 | 1.00 | MAPT (0.42) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL7389769 | 0.99 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL7389775 | 0.99 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL8943367 | 0.84 | MAPT (0.47) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL7392864 | 0.80 | TBXAS1 (0.58) | — | |
| SCHEMBL7395059 | 0.80 | TBXAS1 (0.58) | — | |
| SCHEMBL7392867 | 0.80 | TBXAS1 (0.58) | — | |
| SCHEMBL3750798 | 0.72 | ALDH1A1 (0.54) | MAPTALDH1A1CYP1A2CYP2C9LMNA | |
| SCHEMBL3053729 | 0.72 | CASP6 (0.66) | LMNA | |
| SCHEMBL29115634 | 0.70 | LMNA (0.57) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541325-A | ENZYME INHIBITORS, ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-07-30 | — | — | US | disclosed |
| US-5521187-A | PHOSPHODIESTERASE INHIBITORS, ANTIALLERGENS AND ATOPIC DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-28 | — | — | US | disclosed |
| US-5516908-A | ANTIALLERGENS, ATROPIC DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-14 | — | — | US | disclosed |
| EP-0610372-B1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 1995-12-13 | — | — | EP | disclosed |
| EP-0610372-A1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS. | JANSSEN PHARMACEUTICA NV (BE) | 1994-08-17 | — | — | EP | disclosed |
| WO-1993009118-A1 | 1,3-DIHYDRO-2H-IMIDAZO(4,5-B)QUINOLIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-13 | — | — | WO | disclosed |