Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944792 | 0.80 | KDM4E (0.45) | KDM4EHTTCYP2A13CXCR4ALDH1A1 | |
| SCHEMBL8944755 | 0.77 | LMNA (0.40) | — | |
| SCHEMBL8944902 | 0.69 | CYP2A13 (0.39) | KDM4ECYP2A13ALDH1A1 | |
| SCHEMBL8944501 | 0.68 | KDM4E (0.42) | KDM4EHTTCYP2A13CXCR4ALDH1A1 | |
| SCHEMBL9036092 | 0.66 | KDM4E (0.45) | KDM4ECYP2A13ALDH1A1SIGMAR1TSHR | |
| SCHEMBL8944696 | 0.65 | NISCH (0.41) | KDM4EHTTSIGMAR1 | |
| SCHEMBL8944610 | 0.65 | KMT2A (0.39) | KDM4EHTTALDH1A1PLA2G1BRAB9A | |
| SCHEMBL2387265 | 0.65 | KDM4E (0.44) | KDM4ECYP2A13ALDH1A1SIGMAR1 | |
| SCHEMBL8944498 | 0.64 | TAAR1 (0.42) | — | |
| SCHEMBL8944628 | 0.64 | ADRA2A (0.41) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |