Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944755 | 0.91 | LMNA (0.40) | NISCH | |
| SCHEMBL8944498 | 0.88 | TAAR1 (0.42) | NISCH | |
| SCHEMBL8944628 | 0.83 | ADRA2A (0.41) | ALDH1A1NISCH | |
| SCHEMBL2387265 | 0.83 | KDM4E (0.44) | CYP2A13KDM4EALDH1A1POLBNISCH | |
| SCHEMBL8944681 | 0.82 | MAPK1 (0.43) | KDM4EALDH1A1POLBNISCH | |
| SCHEMBL8944813 | 0.82 | NISCH (0.47) | NISCH | |
| SCHEMBL8944702 | 0.81 | NISCH (0.42) | NISCH | |
| SCHEMBL8944556 | 0.80 | GAA (0.45) | KDM4EALDH1A1POLB | |
| SCHEMBL8944530 | 0.80 | ALDH1A1 (0.46) | KDM4EALDH1A1NISCH | |
| SCHEMBL8944841 | 0.80 | KDM4E (0.45) | KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |