Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386441 | 0.89 | KDM4E (0.47) | SIGMAR1KDM4ETDP1CYP2A13ALDH1A1 | |
| SCHEMBL2387265 | 0.88 | KDM4E (0.44) | SIGMAR1KDM4ETDP1CYP2A13ALDH1A1 | |
| SCHEMBL8944554 | 0.86 | SIGMAR1 (0.44) | SIGMAR1KDM4ECYP2A13ALDH1A1MAPT | |
| SCHEMBL8944590 | 0.82 | KDM4E (0.45) | SIGMAR1KDM4ETDP1CYP2A13ALDH1A1 | |
| SCHEMBL8944610 | 0.79 | KMT2A (0.39) | SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL8944703 | 0.79 | SIGMAR1 (0.41) | SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL8944696 | 0.78 | NISCH (0.41) | SIGMAR1KDM4ENISCH | |
| SCHEMBL8944664 | 0.76 | NISCH (0.48) | SIGMAR1NISCH | |
| SCHEMBL8944513 | 0.75 | SIGMAR1 (0.44) | SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL8944755 | 0.74 | LMNA (0.40) | NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |