Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944554 | 0.92 | SIGMAR1 (0.44) | SIGMAR1KDM4EHTTALDH1A1PLA2G1B | |
| SCHEMBL8944610 | 0.91 | KMT2A (0.39) | SIGMAR1KDM4EHTTALDH1A1PLA2G1B | |
| SCHEMBL8944513 | 0.88 | SIGMAR1 (0.44) | SIGMAR1KDM4EHTTALDH1A1PLA2G1B | |
| SCHEMBL8944696 | 0.87 | NISCH (0.41) | SIGMAR1KDM4EHTTLMNAKMT2A | |
| SCHEMBL8944864 | 0.84 | L3MBTL1 (0.42) | SIGMAR1KDM4EHTTALDH1A1PLA2G1B | |
| SCHEMBL8944769 | 0.83 | ALDH1A1 (0.47) | SIGMAR1KDM4EHTTALDH1A1PLA2G1B | |
| SCHEMBL8944755 | 0.82 | LMNA (0.40) | LMNAKMT2A | |
| SCHEMBL8944786 | 0.80 | CXCR4 (0.42) | SIGMAR1KDM4EHTTALDH1A1PLA2G1B | |
| SCHEMBL8944819 | 0.80 | LMNA (0.38) | KDM4EHTTLMNAKMT2A | |
| SCHEMBL8944853 | 0.79 | SIGMAR1 (0.44) | SIGMAR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |