Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.64 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.64 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 6/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | PPARD | Q03181 | 4/20 | 0.42 |
| ▸ | PPARA | Q07869 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL11015898 | 0.92 | GPR84 (0.59) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Adipic Acid SCHEMBL147794 | 0.89 | LMNA (0.69) | GPR84FFAR1FFAR4LMNATSHR | |
| Adipic Acid SCHEMBL28098837 | 0.89 | LMNA (0.69) | GPR84FFAR1FFAR4LMNATSHR | |
| Adipic Acid SCHEMBL6150285 | 0.89 | LMNA (0.69) | GPR84FFAR1FFAR4LMNATSHR | |
| Adipic Acid SCHEMBL6150292 | 0.89 | LMNA (0.69) | GPR84FFAR1FFAR4LMNATSHR | |
| Pimelic Acid SCHEMBL7457359 | 0.87 | TSHR (0.71) | GPR84FFAR1FFAR4LMNATSHR | |
| Sebacic Acid SCHEMBL5681272 | 0.87 | TSHR (0.71) | GPR84FFAR1FFAR4LMNATSHR | |
| Pimelic Acid SCHEMBL7457377 | 0.87 | TSHR (0.71) | GPR84FFAR1FFAR4LMNATSHR | |
| Sebacic Acid SCHEMBL5681282 | 0.87 | TSHR (0.71) | GPR84FFAR1FFAR4LMNATSHR | |
| Sebacic Acid SCHEMBL10558405 | 0.87 | TSHR (0.71) | GPR84FFAR1FFAR4LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545679-A | CURRENT LIMITERS, RESETTABLE FUSES | EATON CORPORATION (US) | 1996-08-13 | — | — | US | claimed |
| US-5545679-A | CURRENT LIMITERS, RESETTABLE FUSES | EATON CORPORATION (US) | 1996-08-13 | — | — | US | disclosed |