Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Pimelic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 6/20 | 0.55 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.55 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.57 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.57 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.56 |
| ▸ | PPARD | Q03181 | 6/20 | 0.55 |
| ▸ | PPARA | Q07869 | 6/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TLR2 | O60603 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimelic Acid SCHEMBL7457359 | 1.00 | TSHR (0.71) | TSHRLMNANFKB1PMP22ABCC4 | |
| Sebacic Acid SCHEMBL5681282 | 1.00 | TSHR (0.71) | TSHRLMNANFKB1PMP22ABCC4 | |
| Sebacic Acid SCHEMBL10558405 | 1.00 | TSHR (0.71) | TSHRLMNANFKB1PMP22ABCC4 | |
| Sebacic Acid SCHEMBL5681272 | 1.00 | TSHR (0.71) | TSHRLMNANFKB1PMP22ABCC4 | |
| Adipic Acid SCHEMBL6150285 | 0.97 | LMNA (0.69) | TSHRLMNANFKB1PMP22ABCC4 | |
| Adipic Acid SCHEMBL147794 | 0.97 | LMNA (0.69) | TSHRLMNANFKB1PMP22ABCC4 | |
| Adipic Acid SCHEMBL6150292 | 0.97 | LMNA (0.69) | TSHRLMNANFKB1PMP22ABCC4 | |
| Adipic Acid SCHEMBL28098837 | 0.97 | LMNA (0.69) | TSHRLMNANFKB1PMP22ABCC4 | |
| Adipic Acid SCHEMBL28041339 | 0.94 | LMNA (0.65) | TSHRLMNANFKB1PMP22ABCC4 | |
| Sebacic Acid SCHEMBL8897649 | 0.92 | TSHR (0.60) | TSHRLMNANFKB1PMP22ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410494-B1 | — | — | None | — | — | US | claimed |
| US-6410494-B2 | Cleaning agent | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2002-06-25 | — | — | US | claimed |