Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | KDM5A | P29375 | 2/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.56 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.56 |
| ▸ | KDM6B | O15054 | 1/20 | 0.56 |
| ▸ | TET3 | O43151 | 1/20 | 0.56 |
| ▸ | KDM4A | O75164 | 1/20 | 0.56 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.56 |
| ▸ | KDM5C | P41229 | 1/20 | 0.56 |
| ▸ | ASPH | Q12797 | 1/20 | 0.56 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.56 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8945534 | 0.93 | TDP1 (0.60) | TDP1KMT2AJMJD6SLC6A2SLC6A3 | |
| SCHEMBL8945285 | 0.88 | KDM5A (0.56) | TDP1KMT2AJMJD6SLC6A2SLC6A3 | |
| SCHEMBL27525131 | 0.87 | PKM (0.59) | TDP1KMT2AJMJD6SLC6A2SLC6A3 | |
| SCHEMBL19940522 | 0.84 | JMJD6 (0.52) | TDP1KMT2AJMJD6SLC6A2SLC6A3 | |
| SCHEMBL19921398 | 0.84 | JMJD6 (0.52) | TDP1KMT2AJMJD6SLC6A2SLC6A3 | |
| SCHEMBL20858947 | 0.84 | TDP1 (0.60) | TDP1KMT2AJMJD6SLC6A2SLC6A3 | |
| SCHEMBL19682061 | 0.82 | TDP1 (0.58) | TDP1KMT2AJMJD6SLC6A2SLC6A3 | |
| SCHEMBL12486679 | 0.82 | TDP1 (0.58) | TDP1KMT2AJMJD6SLC6A2SLC6A3 | |
| SCHEMBL17559333 | 0.82 | TDP1 (0.58) | TDP1KMT2AJMJD6SLC6A2SLC6A3 | |
| SCHEMBL20305868 | 0.82 | JMJD6 (0.62) | TDP1KMT2AJMJD6SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7002777-A | — | — | None | — | — | JP | disclosed |
| US-5519038-A | ENZYME INHIBITORS SUITABLE AS FIBROSUPPRESSANTS AND IMMUNOSUPPRESSANTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-21 | — | — | US | disclosed |
| JP-H072777-A | 4-OR 5-SUBSTITUTED PYRIDINE-2-CARBOXYLIC ACID, ITS PREPARATION AND ITS USE AS PHARMACEUTICAL | HOECHST AG | 1995-01-06 | — | — | JP | disclosed |