Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8945285 | 0.93 | KDM5A (0.56) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL8945290 | 0.93 | TDP1 (0.58) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL27525131 | 0.92 | PKM (0.59) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL4582464 | 0.85 | L3MBTL1 (0.57) | TDP1KMT2AJMJD6SMN1; SMN2RAB9A | |
| SCHEMBL19921398 | 0.85 | JMJD6 (0.52) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL19940522 | 0.85 | JMJD6 (0.52) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL20858947 | 0.85 | TDP1 (0.60) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL24359749 | 0.84 | L3MBTL1 (0.52) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL18607390 | 0.84 | PKM (0.52) | TDP1KMT2ASLC6A2SLC6A3JMJD6 | |
| SCHEMBL24414106 | 0.84 | TDP1 (0.50) | TDP1KMT2ASLC6A2SLC6A3JMJD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409119-B1 | N,N'-Bis(alkoxy-alkyl)-pyridine-2,4-dicarboxylic acid amides, process for their preparation as well as their use | HOECHST AG (DE) | 1994-04-13 | — | — | EP | claimed |
| US-5519038-A | ENZYME INHIBITORS SUITABLE AS FIBROSUPPRESSANTS AND IMMUNOSUPPRESSANTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-21 | — | — | US | disclosed |
| CN-1060655-A | 4-or 5-substituted pyridines-2-carboxylic acid, their preparation method and medicinal | HOECHST AG (DE) | 1992-04-29 | — | — | CN | disclosed |