Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ASPH | Q12797 | 5/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 5/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL241097 | 0.83 | KDM4E (0.38) | KDM4EL3MBTL1PARP1SIRT1ALDH1A1 | |
| SCHEMBL3677819 | 0.83 | BRAF (0.34) | KDM4EBRAFLRRK2 | |
| SCHEMBL27699318 | 0.81 | NOS2 (0.41) | KDM4EBRAFSIRT3TDP1LRRK2 | |
| SCHEMBL8842626 | 0.81 | KDM4E (0.40) | KDM4EL3MBTL1ASPHKDM8PARP1 | |
| SCHEMBL19439176 | 0.81 | CCNC (0.41) | KDM4EL3MBTL1ASPHKDM8PARP1 | |
| SCHEMBL29421066 | 0.77 | SIRT1 (0.39) | KDM4EPARP1SIRT1ALDH1A1HPGD | |
| SCHEMBL7109139 | 0.77 | SIRT1 (0.39) | KDM4EPARP1SIRT1ALDH1A1HPGD | |
| SCHEMBL8321873 | 0.74 | KDM4E (0.47) | KDM4EL3MBTL1ASPHKDM8PARP1 | |
| SCHEMBL27800518 | 0.74 | SIRT1 (0.47) | KDM4EPARP1SIRT1ALDH1A1HPGD | |
| SCHEMBL28972443 | 0.72 | ASPH (0.41) | KDM4EASPHKDM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112204009-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2024-05-07 | — | — | CN | disclosed |
| US-5519038-A | ENZYME INHIBITORS SUITABLE AS FIBROSUPPRESSANTS AND IMMUNOSUPPRESSANTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-21 | — | — | US | disclosed |