Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8945357 | 0.83 | KDM4E (0.38) | BRAFLRRK2KDM4E | |
| SCHEMBL27699318 | 0.81 | NOS2 (0.41) | BRAFLRRK2KMT2AKDM4ENR3C2 | |
| SCHEMBL3673649 | 0.77 | KDM4E (0.46) | KDM4ECYP1A2MAPT | |
| SCHEMBL8598306 | 0.75 | NOS3 (0.39) | BRAFMAP2K3KMT2AKDM4ECYP1A2 | |
| SCHEMBL28208498 | 0.75 | CCNC (0.39) | BRAFMAP2K3KMT2AKDM4ECYP1A2 | |
| SCHEMBL6022177 | 0.74 | NOS2 (0.43) | KDM4EMAPT | |
| SCHEMBL4745637 | 0.72 | KMT2A (0.31) | KMT2A | |
| SCHEMBL27583503 | 0.72 | ADORA3 (0.36) | BRAFLRRK2KMT2A | |
| SCHEMBL27719840 | 0.70 | NOS2 (0.42) | BRAFKMT2AKDM4ENR3C2 | |
| SCHEMBL31275306 | 0.70 | L3MBTL1 (0.34) | MAP2K3KMT2AKDM4ENR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |
| CN-105078652-B | Intelligent compression system based on shape memory material | 香港理工大学 | 2019-03-15 | — | — | CN | disclosed |
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |