SCHEMBL8945768

SCHEMBL8945768

CNC(Cc1ccccc1O)c1sccc1C

nearest known ligand 0.71

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSPA5 P11021 1/20 0.38
MAPT P10636 3/20 0.37
MEN1 O00255 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HTT P42858 1/20 0.37
KMT2A Q03164 1/20 0.37
CYP3A4 P08684 2/20 0.36
CYP2D6 P10635 2/20 0.36
SLC6A2 P23975 2/20 0.36
SLC6A4 P31645 2/20 0.36
SLC6A3 Q01959 2/20 0.36
KCNH2 Q12809 2/20 0.36
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8946070 0.99 MAPT (0.39) HSPA5MAPTMEN1ALDH1A1HTT
SCHEMBL9425146 0.84 CXCR1 (0.34) MAPTALDH1A1KMT2A
SCHEMBL8946017 0.83 ALOX5 (0.33) ALDH1A1KMT2ACYP3A4HPGD
SCHEMBL8946053 0.81 HPGD (0.40) MAPTALDH1A1CYP3A4CYP2D6SLC6A2
Hydrochloric Acid SCHEMBL8945983 0.80 CYP2D6 (0.42) MAPTALDH1A1CYP3A4CYP2D6SLC6A2
SCHEMBL8946095 0.79 ALDH1A1 (0.43) MAPTMEN1ALDH1A1KMT2AHPGD
SCHEMBL8760252 0.79 TAAR1 (0.44) CYP2D6SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL9482849 0.78 TAAR1 (0.43) CYP2D6
SCHEMBL8761001 0.78 MEN1 (0.41) MAPTMEN1ALDH1A1KMT2AHPGD
SCHEMBL9676214 0.77 TSHR (0.37) MAPTMEN1ALDH1A1HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5292760-A 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1994-03-08 US claimed
US-5510346-A ANTIDEPRESSANTS, ANTIANXIETY AGENTS HOECHST MARION ROUSSEL, INC. (US) 1996-04-23 US disclosed
US-5292760-A 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1994-03-08 US disclosed
EP-0322582-A2 4-Heteroaryl-1,3-Benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1989-07-05 EP disclosed