Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425204 | 0.87 | CETP (0.39) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL9425146 | 0.86 | CXCR1 (0.34) | ALDH1A1MAPTKMT2ACXCR1CXCR2 | |
| SCHEMBL8945768 | 0.79 | HSPA5 (0.38) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8946070 | 0.78 | MAPT (0.39) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL8946017 | 0.77 | ALOX5 (0.33) | ALDH1A1HPGDKMT2A | |
| SCHEMBL9425074 | 0.76 | MAPT (0.39) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL9425072 | 0.76 | CETP (0.38) | ALDH1A1MAPTTSHRMEN1GAA | |
| SCHEMBL8946053 | 0.74 | HPGD (0.40) | ALDH1A1HPGDMAPTGAA | |
| SCHEMBL9425081 | 0.74 | PGR (0.40) | ALDH1A1HPGDMAPTMEN1GAA | |
| SCHEMBL8761001 | 0.74 | MEN1 (0.41) | ALDH1A1HPGDMAPTTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | claimed |
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0322582-A2 | 4-Heteroaryl-1,3-Benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-07-05 | — | — | EP | disclosed |