Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8945896 | 0.97 | HTT (0.33) | HTTKDM4EHSD17B10PDE5AALDH1A1 | |
| SCHEMBL8945967 | 0.85 | HRH4 (0.34) | HTTKDM4EHSD17B10PDE5AALDH1A1 | |
| SCHEMBL8946140 | 0.85 | HTT (0.32) | HTTKDM4EHSD17B10PDE5AALDH1A1 | |
| SCHEMBL8946006 | 0.85 | HTT (0.32) | HTTKDM4EHSD17B10PDE5AALDH1A1 | |
| SCHEMBL8945973 | 0.85 | MEN1 (0.36) | HTTKDM4EHSD17B10PDE5AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8945756 | 0.84 | HRH4 (0.34) | HTTKDM4EHSD17B10PDE5AHRH4 | |
| Hydrochloric Acid SCHEMBL8945964 | 0.84 | HTT (0.32) | HTTKDM4EHSD17B10PDE5A | |
| Hydrochloric Acid SCHEMBL8945828 | 0.83 | HTT (0.31) | HTTPDE5A | |
| SCHEMBL8945957 | 0.83 | HTT (0.31) | HTTPDE5ACTSD | |
| SCHEMBL8945958 | 0.82 | HRH4 (0.32) | MEN1KMT2AHRH4CYP2D6RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | claimed |
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | disclosed |