Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.30 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11270824 | 0.81 | CHRNB2 (0.37) | CYP2D6MEN1RECQLKMT2A | |
| SCHEMBL8946002 | 0.79 | CYP2D6 (0.33) | CYP2D6MEN1RECQLKMT2A | |
| SCHEMBL8946144 | 0.78 | CYP19A1 (0.34) | HRH4CYP2D6RECQLKMT2A | |
| SCHEMBL8946051 | 0.78 | NPEPPS (0.37) | — | |
| SCHEMBL9583461 | 0.78 | MAOA (0.40) | MEN1KMT2A | |
| Water SCHEMBL8945782 | 0.77 | CYP19A1 (0.33) | HRH4CYP2D6KMT2A | |
| SCHEMBL9582906 | 0.77 | MAOB (0.41) | CCR3 | |
| SCHEMBL9582581 | 0.77 | MAOB (0.41) | KMT2A | |
| SCHEMBL9584219 | 0.77 | MAOB (0.41) | CCR3MEN1KMT2A | |
| SCHEMBL9582044 | 0.77 | NPY1R (0.36) | CCR3MEN1RECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0322582-A2 | 4-Heteroaryl-1,3-Benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-07-05 | — | — | EP | disclosed |