Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | DGKA | P23743 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260215 | 0.95 | TSHR (0.62) | TDP1TSHRHPGDCES2HCAR2 | |
| SCHEMBL19296598 | 0.89 | TDP1 (0.67) | TDP1TSHRHPGDCES2ALDH1A1 | |
| SCHEMBL7767124 | 0.86 | TSHR (0.52) | TDP1TSHRHPGDATMALDH1A1 | |
| SCHEMBL194073 | 0.81 | TSHR (0.46) | TDP1TSHRHPGDCES2ATM | |
| SCHEMBL8670951 | 0.81 | TDP1 (0.61) | TDP1TSHRHPGDALDH1A1HSD17B10 | |
| SCHEMBL1055702 | 0.81 | ALDH1A1 (0.54) | TDP1TSHRHPGDCES2ATM | |
| SCHEMBL3430807 | 0.80 | TDP1 (0.63) | TDP1TSHRHPGDALDH1A1HSD17B10 | |
| SCHEMBL27579881 | 0.80 | TDP1 (0.79) | TDP1TSHRHPGDCES2ALDH1A1 | |
| SCHEMBL31443222 | 0.80 | TSHR (0.61) | TDP1TSHRHPGDATMALDH1A1 | |
| SCHEMBL28665486 | 0.80 | TSHR (0.61) | TDP1TSHRHPGDATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5493027-A | ANTIEPILEPTIC AGENTS, NEUROGENATIVE DISEASES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1996-02-20 | — | — | US | disclosed |
| WO-1994017042-A1 | ANTICONVULSIVE AGENTS AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1994-08-04 | — | — | WO | disclosed |