Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946497 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946506 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946433 | 0.82 | SLC6A2 (0.40) | KDM4EALDH1A1MAPTOPRM1CHRNB2 | |
| SCHEMBL8946437 | 0.82 | SLC6A2 (0.40) | KDM4EALDH1A1MAPTOPRM1CHRNB2 | |
| SCHEMBL8946442 | 0.82 | SLC6A2 (0.40) | KDM4EALDH1A1MAPTOPRM1CHRNB2 | |
| SCHEMBL10380873 | 0.81 | HPGD (0.55) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946743 | 0.81 | ADRA2A (0.41) | OPRM1OPRK1CHRNB2CHRNA4HTR2A | |
| SCHEMBL8946720 | 0.81 | ADRA2A (0.41) | OPRM1OPRK1CHRNB2CHRNA4HTR2A | |
| SCHEMBL8946747 | 0.81 | ADRA2A (0.41) | OPRM1OPRK1CHRNB2CHRNA4HTR2A | |
| SCHEMBL24300090 | 0.81 | OPRM1 (0.41) | OPRM1OPRK1HTR2ASLC6A2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |