Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946592 | 0.89 | LPAR1 (0.47) | KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL8946926 | 0.86 | NTRK1 (0.53) | S1PR4NTRK1KMT2ACRHBPCRHR2 | |
| SCHEMBL8946542 | 0.84 | ANPEP (0.40) | S1PR4NTRK1ANPEPCNR1POLB | |
| SCHEMBL8946397 | 0.84 | S1PR4 (0.39) | S1PR4NTRK1ANPEPCNR1LMNA | |
| SCHEMBL8946576 | 0.84 | L3MBTL1 (0.51) | ALDH1A1NTRK1MAPTANPEPCNR1 | |
| SCHEMBL8946713 | 0.81 | L3MBTL1 (0.41) | S1PR4NTRK1CNR1 | |
| SCHEMBL8946528 | 0.81 | LMNA (0.41) | ALDH1A1KDM4ES1PR4MAPTANPEP | |
| SCHEMBL8946727 | 0.80 | LMNA (0.43) | ALDH1A1S1PR4MAPTCNR1MEN1 | |
| SCHEMBL8946840 | 0.79 | TP53 (0.42) | ALDH1A1KDM4ES1PR4MAPTPOLB | |
| SCHEMBL8946520 | 0.78 | PIK3R1 (0.43) | ALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500424-A | ENZYME INHIBITORS | NIHON NOHYAKU CO., LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0638557-A1 | N-phenylpyri(mi)dine-N'-phenyl-urea derivatives, their preparation and their use as ACAT inhibitors | NIHON NOHYAKU CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |