Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946672 | 1.00 | HTR2A (0.40) | HTR2AHTR2CHTR2BALDH1A1KDM4E | |
| SCHEMBL8946679 | 1.00 | HTR2A (0.40) | HTR2AHTR2CHTR2BALDH1A1KDM4E | |
| SCHEMBL9844749 | 0.81 | HTR2A (0.34) | HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL9844750 | 0.81 | HTR2A (0.34) | HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL9844752 | 0.81 | HTR2A (0.34) | HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL9844734 | 0.70 | ALDH1A1 (0.43) | HTR2AHTR2CHTR2BALDH1A1MAPT | |
| SCHEMBL9844730 | 0.70 | ALDH1A1 (0.43) | HTR2AHTR2CHTR2BALDH1A1MAPT | |
| SCHEMBL9844732 | 0.70 | ALDH1A1 (0.43) | HTR2AHTR2CHTR2BALDH1A1MAPT | |
| SCHEMBL8946329 | 0.68 | CYP3A4 (0.35) | HTR2AHTR2CHTR2BALDH1A1KMT2A | |
| SCHEMBL8946323 | 0.68 | CYP3A4 (0.35) | HTR2AHTR2CHTR2BALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |