Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946762 | 0.86 | NTRK1 (0.45) | NTRK1NTRK3MAPTLMNANTRK2 | |
| SCHEMBL8946441 | 0.86 | NTRK1 (0.48) | NTRK1NTRK3ALDH1A1MAPTLMNA | |
| SCHEMBL8946563 | 0.86 | NTRK1 (0.57) | NTRK1NTRK3ALDH1A1MAPTLMNA | |
| SCHEMBL8946567 | 0.83 | NTRK1 (0.45) | NTRK1NTRK3ALDH1A1MAPTLMNA | |
| SCHEMBL8946576 | 0.83 | L3MBTL1 (0.51) | NTRK1NTRK3ALDH1A1MAPTLMNA | |
| SCHEMBL8946624 | 0.82 | NTRK1 (0.43) | NTRK1NTRK3ALDH1A1MAPTLMNA | |
| SCHEMBL8946671 | 0.82 | NTRK1 (0.48) | NTRK1NTRK3ALDH1A1MAPTLMNA | |
| SCHEMBL8946507 | 0.81 | NTRK1 (0.44) | NTRK1MAPK1TP53MEN1KMT2A | |
| SCHEMBL8946363 | 0.80 | NTRK1 (0.51) | NTRK1NTRK3ALDH1A1MAPTLMNA | |
| SCHEMBL8946498 | 0.79 | NTRK1 (0.47) | NTRK1NTRK3MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500424-A | ENZYME INHIBITORS | NIHON NOHYAKU CO., LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0638557-A1 | N-phenylpyri(mi)dine-N'-phenyl-urea derivatives, their preparation and their use as ACAT inhibitors | NIHON NOHYAKU CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |